Graduate School

Modern trends in molecular biology and biotechnology II

This course is part of the programme:
Molecular Genetics and Biotechnology graduate study programme (Third Level)

Objectives and competences

The primary aim of the course is to transmit state of art knowledge in the filed of molecular genetics, molecular biology and biotechnology. Students have the possibility to interact an international panel of scientist expert in different disciplines. The participation of activities is an invaluable occasion of scientific and cultural growth offered to students that are strongly advised to actively participate to the scientific community within an international research centre.

To improve student critic attitude, a series of Journal Clubs is proposed, where PhD students study, understand and discuss selected literature. Journal clubs distributed throughout the year, and are chaired by a different group leaders.

Student can propose a seminar wish list to the PhD organizer committee for consideration and selection.

Student can propose to present a scientific article related to his/her own interest.

Prerequisites

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Content (Syllabus outline)

  • Seminars in different fields of molecular biology, molecular genetics, biomedicine and biotechnology given by invited international speakers top experts in the field.
  • Journal Clubs, chaired by different lab group leaders. The selected literature could be either related to one of the seminar or selected among interesting papers recently published.
  • Integration in a scientific cultural and research community

Intended learning outcomes

Students of the second year have a deeper understanding of actual trends in molecular genetics, biology ad biotechnology. Students learn ways of interactive and critic scientific discussion. It is expected that students critically interact during seminars with questions and discussion. Students are self propose Journal club activities to reinforce communication and discussion of a published literature.

Readings

Selected literature related to scientific seminars and Journal Clubs.

Assessment

Active attendance to proposed activities. 100%

Lecturer's references

Distinguished invited speakers and scientists in molecular bioloy at the University of Nova Gorica and ICGEB.

Prof. dr. Mauro Giacca is Professor at University of Trieste.

Bibliography:

1. Zecchin A, Pattarini L, Gutierrez MI, Mano M, Mai A, Valente S, Myers MP, Pantano S, Giacca M. Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity. J Mol Cell Biol. 2014 Apr;6(2):116-27.

2. Eulalio A, Mano M, Dal Ferro M, Zentilin L, Sinagra G, Zacchigna S, Giacca M. Functional screening identifies miRNAs inducing cardiac regeneration. Nature. 2012 Dec 20;492(7429):376-81.

3. Lovric J, Mano M, Zentilin L, Eulalio A, Zacchigna S, Giacca M. Terminal differentiation of cardiac and skeletal myocytes induces permissivity to AAV transduction by relieving inhibition imposed by DNA damage response proteins. Mol Ther. 2012 Nov;20(11):2087-97.

4. Maione F, Capano S, Regano D, Zentilin L, Giacca M, Casanovas O, Bussolino F, Serini G, Giraudo E. Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice. J Clin Invest. 2012 May 1;122(5):1832-48.

5. Giacca M, Baker AH. Heartening results: the CUPID gene therapy trial for heart failure. Mol Ther. 2011 Jul;19(7):1181-2.

University course code: 8MG006

Year of study: 2

Semester: 1-2

Course principal:

ECTS: 10

Workload:

  • Seminar: 75 hours
  • Individual work: 225 hours

Course type: compulsory

Languages: english

Learning and teaching methods:
• active participation to seminars sections • active participation to journal club activities • proposal of seminar topics or extra journal club sections • individual work, study of the literature • ability to critically integrate and interpret new information and knowledge.